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Amgen Engineering

To leverage cutting-edge technology and computational biology to discover and develop life-changing medicines for patients with serious illnesses

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Align the strategy

Amgen Engineering SWOT Analysis

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To leverage cutting-edge technology and computational biology to discover and develop life-changing medicines for patients with serious illnesses

Strengths

  • PLATFORM: Robust computational biology and digital platforms
  • EXPERTISE: Deep experience in bioinformatics and data science
  • INFRASTRUCTURE: State-of-the-art cloud computation resources
  • RESOURCES: Strong financial position with $9.7B in revenue Q1 2023
  • INTEGRATION: Successful tech integration from acquisitions

Weaknesses

  • TECHNICAL_DEBT: Legacy systems slowing innovation velocity
  • TALENT: Gaps in specialized AI and machine learning expertise
  • COLLABORATION: Siloed development across therapeutic areas
  • PROCESSES: Slow validation protocols for computational methods
  • SCALE: Limited digital infrastructure for next-gen data volume

Opportunities

  • PRECISION: Expansion of precision medicine requiring tech support
  • DATA: Increasing availability of multi-omics patient data
  • PARTNERSHIPS: Academic and tech collaborations for innovation
  • AUTOMATION: Lab automation to increase experimental throughput
  • REGULATORY: FDA modernization for computational model validation

Threats

  • COMPETITION: Big tech firms entering biotech computation space
  • COMPLEXITY: Increasing data size outpacing analysis capabilities
  • SECURITY: Growing cybersecurity threats to sensitive research
  • TALENT_WAR: Fierce competition for specialized tech talent
  • REGULATION: Evolving compliance requirements for AI in healthcare

Key Priorities

  • MODERNIZATION: Accelerate legacy system modernization
  • AI_TALENT: Recruit and develop specialized AI talent
  • INTEGRATION: Break down data silos across therapeutic areas
  • SECURITY: Strengthen cybersecurity for sensitive research data
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Align the plan

Amgen Engineering OKR Plan

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To leverage cutting-edge technology and computational biology to discover and develop life-changing medicines for patients with serious illnesses

MODERNIZE

Accelerate digital transformation of core platforms

  • LEGACY: Retire 80% of legacy systems identified in tech debt audit by Q3 2025 with zero research disruption
  • CLOUD: Achieve 95% cloud migration of research computing workloads with 30% performance improvement
  • PLATFORMS: Launch 3 next-gen computational biology platforms with 99.9% uptime and 50% faster processing
  • AUTOMATION: Implement lab automation integration in 5 key research areas reducing manual work by 60%
UNITE DATA

Break down data silos across the enterprise

  • ARCHITECTURE: Deploy unified data architecture across all therapeutic areas with 100% data accessibility
  • STANDARDS: Implement data standards for 90% of research data types with automated quality validation
  • INTEGRATION: Connect 15 disparate data sources into central data lake with real-time synchronization
  • GOVERNANCE: Establish enterprise data governance council with 100% therapeutic area representation
AI ACCELERATION

Lead the industry in AI-driven drug discovery

  • MODELS: Deploy 5 production-grade AI models for target identification with 40% increased accuracy
  • TALENT: Hire and onboard 25 specialized AI engineers and computational biologists by Q3
  • VALIDATION: Implement AI validation framework meeting FDA guidance across 100% of AI initiatives
  • PLATFORMS: Launch integrated AI platform supporting all therapeutic areas with daily model retraining
SECURE FUTURE

Establish world-class research cybersecurity

  • ASSESSMENT: Complete comprehensive security assessment of all research systems with remediation plan
  • PROTOCOLS: Implement zero-trust architecture for 100% of sensitive research data access points
  • MONITORING: Deploy advanced threat detection across all research platforms with <15min response time
  • TRAINING: Achieve 100% completion rate for cybersecurity training with 90% phishing test pass rate
METRICS
  • TIME-TO-MARKET: 20% reduction in therapeutic candidate discovery to IND filing
  • COMPUTATIONAL EFFICIENCY: 40% increase in computing throughput per dollar spent
  • DATA INTEGRATION: 85% of research data accessible through unified platforms
VALUES
  • Be science-based
  • Compete intensely and win
  • Create value for patients, staff and stockholders
  • Be ethical
  • Trust and respect each other
  • Ensure quality
  • Work in teams
  • Collaborate, communicate and be accountable
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Align the learnings

Amgen Engineering Retrospective

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To leverage cutting-edge technology and computational biology to discover and develop life-changing medicines for patients with serious illnesses

What Went Well

  • PERFORMANCE: Q4 2023 revenue grew 20% YoY to $8.2B exceeding estimates
  • PIPELINE: Five successful Phase 3 trials supported by computation
  • EFFICIENCY: Tech-enabled R&D cost reduction of 8% while increasing output
  • ACQUISITION: Successful integration of Horizon Therapeutics tech systems
  • INFRASTRUCTURE: Completed cloud migration of 85% of computing workloads

Not So Well

  • DELAYS: Three computational biology platforms missed launch deadlines
  • ATTRITION: Lost 15% of senior tech talent to competitors and tech firms
  • INTEGRATION: Data integration challenges slowed cross-program insights
  • COSTS: Cloud computing costs exceeded budget by 22% with low utilization
  • SECURITY: Two significant data security incidents requiring remediation

Learnings

  • COMPLEXITY: Underestimated complexity of multi-omics data integration
  • STANDARDS: Need for standardized data formats across research programs
  • TRAINING: Insufficient training on new computational biology platforms
  • GOVERNANCE: Weak governance model for enterprise data strategy execution
  • PARTNERSHIPS: External tech partnerships delivered more value than DIY

Action Items

  • ESTABLISH: Enterprise data governance with cross-functional leadership
  • PRIORITIZE: Define critical computational platforms for strategic focus
  • DEVELOP: Comprehensive tech talent acquisition and retention strategy
  • IMPLEMENT: Standard data architecture across therapeutic areas by Q4
  • OPTIMIZE: Cloud resource management to reduce costs by 25% within 6M
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Drive AI transformation

Amgen Engineering AI Strategy SWOT Analysis

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To leverage cutting-edge technology and computational biology to discover and develop life-changing medicines for patients with serious illnesses

Strengths

  • FOUNDATION: Early investment in AI for drug discovery
  • EXPERTISE: Core team of computational biology AI specialists
  • DATA: Extensive proprietary clinical and genetic datasets
  • INFRASTRUCTURE: Established high-performance computing resources
  • LEADERSHIP: Executive commitment to AI transformation

Weaknesses

  • FRAGMENTATION: Disparate AI initiatives across divisions
  • SKILLSETS: Limited ML engineering talent for production systems
  • INTEGRATION: Poor integration of AI insights into decision making
  • VALIDATION: Insufficient protocols for AI model validation
  • SCALE: Limited ability to scale successful AI prototypes

Opportunities

  • DISCOVERY: AI to reduce candidate identification time by 40%
  • CLINICAL: ML for optimizing clinical trial design and execution
  • MANUFACTURING: AI to improve production efficiency and quality
  • PARTNERSHIPS: Strategic AI partnerships with tech leaders
  • PERSONALIZATION: AI-driven precision medicine solutions

Threats

  • COMPETITORS: Major pharma companies' aggressive AI investments
  • TECH_GIANTS: Google, Microsoft entering drug discovery space
  • REGULATION: Uncertain regulatory landscape for AI in healthcare
  • COST: Increasing costs for AI infrastructure and talent
  • TRANSPARENCY: Growing demands for AI explainability in healthcare

Key Priorities

  • UNIFICATION: Create unified AI strategy across therapeutic areas
  • TALENT: Build specialized AI for drug discovery talent pipeline
  • VALIDATION: Develop robust AI validation frameworks
  • INFRASTRUCTURE: Invest in scalable AI/ML infrastructure